Anti-aquaporin 4 autoantibodies in patients with systemic lupus erythematosus without CNS involvement: a long-term assessment

withdrawn EP4258 Cerebral vasculitis: a report of 17 cases Y. Cherif1, S. Younes1, H. Haj Kacem1, O. Berriche1, H. Hamza2, S. Jerbi2, M.H. Sfar1 1Internal Medicine and Endocrinology, 2Radiology, Tahar Sfar University Hospital, Mahdia, Tunisia Introduction: Cerebral vasculitis (CV) is rare. They may be primary or related to systemic, infectious or neoplastic diseases. Methods: Retrospective study of 17 cases of CV. All patients underwent a neurological and ophthalmological examination, cerebral imaging and immunological analysis. Results: There were 11men and 6 women, whose mean age: 56 years (25-75 years). The history was noteworthy with arterial hypertension in 1 patient, diabetes in 2 patients, pulmonary embolism in 1patient, retinal vasculitis in 1 patient and meningioma in 1 patient. The CV was diagnosed at primarily motor impairment in 6 patients, headache in 4 patients, dementia in 2 patients, intracranial hypertension in 2 patients, coma and in 1patient and psychiatric disorders in 2 patients. Five patients had generalized tonic-clonic seizures. All patients had T2 hyperintensities in the periventricular white matter in 13cases, in the brainstem 2 cases and in the cerebellum in 2 cases. CV was secondary to Behçet’s disease in 5cases, Sjogren’s syndrome in 4 cases, giant cell arteritis in 3 cases, systemic lupus erythematosus in 2 cases, antiphospholipid syndrome in 2 cases and Susac syndrome in 1 case. All patients were treated with high dose corticosteroids regimen, associated with Cyclophosphamide in 2 cases, Azathioprine in 2 cases, anticoagulant drugs in 3 cases and antiplatelet drugs in 13 cases. The outcomes were quite favorable with complete or partial recovery of neurological deficit in 16 cases and disappearance of psychiatric disorders in 1 patient. Conclusions: We present different clinical features of CV, main causes, its management and prognosis. The diagnosis is held on a basis of clinical, biological and MR findings even if the definite diagnosis is based on cerebral biopsy. Disclosure: Nothing to disclose